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Two recognizable options of incentive salience are often visible that can be utilized in neuroscience experiments: (i) UCS-directed 'wanting' - CS-triggered pulses of intensified 'wanting' for the UCS reward; and (ii) CS-directed 'wanting' - motivated attraction to the Pavlovian cue, which makes the arbitrary CS stimulus into a motivational magnet.
PMC 3325516. PMID 22487042. Here I focus on how mesocorticolimbic mechanisms generate the motivation component of incentive salience. Here we tested the consequences of DOI on head-twitch conduct (HTR) - a mouse behavioral proxy of human psychedelic potential - in male and female mice.

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Malenka RC, Nestler EJ, Hyman SE (2009). Sydor A, Brown RY (eds.). Pelchat ML (March 2009). "Food Addiction in Humans". Manubay JM, Muchow C, Sullivan MA (March 2011). "Prescription drug abuse: epidemiology, regulatory issues, chronic pain administration with narcotic analgesics".
A significant milestone was reached on March 14, 2016, when the American Board of Medical Specialties (ABMS) formally introduced recognition of the sector of Addiction Medicine as a medical subspecialty.

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